Cagrilintide: GLP-1 Booster (10mg)

💜Cagrilintide binds to the amylin receptors in the brain, which helps modulate
appetite and enhance feelings of fullness or satiety. Amylin plays a crucial role in
regulating appetite, satiety, and glucose metabolism. By enhancing the effects of
amylin. Cagrilintide helps to control hunger, promote feelings of fullness. and improve
overall metabolic function.
💜 Benefits: Reduced appetite and cravings. Improved metabolism and blood sugar
control.
💜 Complementary to GLP-1 like Semaglutide, Tirzepatide and Retatrutide: When
used in combination with GLP-1 agonists, it has shown enhanced weight loss
compared to either drug alone.
💜🧡 Mean reduction in body weight from baseline to week 26: 💜🧡
● Cagrilintide 0.3 mg: 6.0%
● Cagrilintide 0.6 mg: 6.8%
● Cagrilintide 1.2 mg: 9.1%
● Cagrilintide 2.4 mg: 9.7%
● Cagrilintide 4.5 mg: 10.8%

Administration:

• Route: Subcutaneous injection

• Frequency: Once weekly

Dosing (based on Phase 1b and 2 studies):

• Initiation (Titration Phase):

  • Start at 0.3 mg once weekly

  • Gradually titrate up in 0.3 mg increments every 4 weeks to minimize gastrointestinal side effects

• Maintenance Dose:

  • Target dose range: 1.2 mg to 4.5 mg weekly

  • Final dose selection based on tolerability and treatment response

Combination Therapy:

• In trials, Cagrilintide was most effective when used with Semaglutide 2.4 mg/week, suggesting a dual hormone strategy for enhanced weight reduction.