Tirzepatide is a synthetic peptide that acts as a dual agonist of two key metabolic receptors:
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- GLP-1 (Glucagon-Like Peptide-1) receptor
- GIP (Glucose-Dependent Insulinotropic Polypeptide) receptor
- Structurally, it is a 39-amino acid peptide that combines elements of native GIP and GLP-1 sequences, modified to resist enzymatic degradation and extend its half-life (~5 days).
- Designed for once-weekly subcutaneous injection, it mimics natural gut hormones involved in regulating glucose and appetite.
Benefits:
Tirzepatide has shown clinically significant outcomes across several therapeutic areas:
- Type 2 Diabetes Management:
- Improves glycemic control by enhancing insulin secretion and reducing glucagon levels.
- Reduces HbA1c significantly, often more than GLP-1 receptor agonists alone.
- Weight Loss & Obesity Treatment:
- Demonstrates substantial body weight reduction in both diabetic and non-diabetic individuals.
- Acts on appetite regulation and delays gastric emptying, promoting a feeling of fullness.
- Cardiometabolic Improvements:
- Modest improvements in lipid profiles, blood pressure, and inflammatory markers have been observed.
- Ongoing studies are evaluating long-term cardiovascular benefits.
- Liver Health:
- Early evidence suggests potential benefits in non-alcoholic fatty liver disease (NAFLD) due to weight reduction and insulin sensitivity improvements.
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