Tirzepatide 15mg

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Tirzepatide is a once-weekly injectable peptide that acts as a dual GLP-1 and GIP receptor agonist, designed to improve blood sugar control and support significant weight loss. Originally developed for type 2 diabetes, it has shown powerful effects in reducing HbA1c levels and promoting sustained weight reduction in both diabetic and non-diabetic individuals. By enhancing insulin secretion, suppressing appetite, and slowing gastric emptying, tirzepatide supports metabolic health and may offer additional benefits for heart and liver function. Common side effects include nausea and digestive discomfort, typically easing with gradual dose escalation.

Tirzepatide is a synthetic peptide that acts as a dual agonist of two key metabolic receptors:

    • GLP-1 (Glucagon-Like Peptide-1) receptor
    • GIP (Glucose-Dependent Insulinotropic Polypeptide) receptor
  • Structurally, it is a 39-amino acid peptide that combines elements of native GIP and GLP-1 sequences, modified to resist enzymatic degradation and extend its half-life (~5 days).
  • Designed for once-weekly subcutaneous injection, it mimics natural gut hormones involved in regulating glucose and appetite.

Benefits:

Tirzepatide has shown clinically significant outcomes across several therapeutic areas:

  • Type 2 Diabetes Management:
    • Improves glycemic control by enhancing insulin secretion and reducing glucagon levels.
    • Reduces HbA1c significantly, often more than GLP-1 receptor agonists alone.
  • Weight Loss & Obesity Treatment:
    • Demonstrates substantial body weight reduction in both diabetic and non-diabetic individuals.
    • Acts on appetite regulation and delays gastric emptying, promoting a feeling of fullness.
  • Cardiometabolic Improvements:
    • Modest improvements in lipid profiles, blood pressure, and inflammatory markers have been observed.
    • Ongoing studies are evaluating long-term cardiovascular benefits.
  • Liver Health:
    • Early evidence suggests potential benefits in non-alcoholic fatty liver disease (NAFLD) due to weight reduction and insulin sensitivity improvements.

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