Composition
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SS‑31, also known as Elamipretide, is a synthetic tetrapeptide composed of four amino acids: D‑Arg‑dimethylTyr‑Lys‑Phe‑NH₂. It’s specifically designed to target the inner mitochondrial membrane, where it binds to the lipid cardiolipin, helping stabilize mitochondrial structure and reduce oxidative damage.
Benefits
SS‑31 offers a wide range of potential therapeutic effects, all tied to enhancing mitochondrial health and function:
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Improved mitochondrial energy production
Enhances ATP generation in tissues with high energy demands—like the heart, brain, and muscles. May boost endurance and reduce fatigue. -
Cardioprotection & tissue resilience
Demonstrated benefits include reduced damage from ischemia-reperfusion injury and heart failure models. -
Neuroprotection & brain health
May protect against cognitive decline and neurodegenerative conditions (e.g., Alzheimer’s, Parkinson’s, ALS) by safeguarding mitochondrial function. -
Visual function improvement
Clinical trials in patients with age-related macular degeneration (AMD) suggest SS‑31 may enhance low-light vision and reading acuity. -
Kidney support & anti-fibrotic effects
In various kidney disease models, SS‑31 improved renal function, reduced fibrosis, and protected mitochondrial integrity. -
Metabolic benefits
Animal studies show potential improvements in insulin sensitivity and liver health. -
Anti-aging potential
In aged mice, SS‑31 increased lifespan, improved muscle strength, and overall healthspan.
Reviews
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