Retatrutide 20mg

Composition of Retatrutide:

• Retatrutide is a synthetic peptide that functions as a triple hormone receptor agonist, targeting:

  • GLP-1 (Glucagon-Like Peptide-1) receptor

  • GIP (Glucose-Dependent Insulinotropic Polypeptide) receptor

  • Glucagon receptor

• It consists of a 39-amino acid sequence structurally related to native GLP-1 and GIP peptides, with engineered modifications to enhance:

  • Stability

  • Half-life extension (approximately 5–7 days)

  • Receptor binding affinity

• Molecular weight: Approximately 4,700–5,000 Da, depending on the specific formulation and modifications used in clinical trials.

Benefits of Using Retatrutide:

Retatrutide is currently in phase 2 clinical trials and has demonstrated significant promise in early data. Potential benefits include:

• Substantial Weight Loss

  • In clinical studies, retratrutide has shown unprecedented reductions in body weight, with average losses exceeding 20% in non-diabetic individuals over 48 weeks — surpassing the effects of both GLP-1 and dual agonists alone.
    (Ref: Jastreboff et al., 2023 – NEJM)

• Improved Metabolic Health

  • Enhances insulin sensitivity

  • Reduces fasting glucose and HbA1c levels in individuals with prediabetes or type 2 diabetes

• Appetite Suppression & Satiety

  • Acts on appetite-regulating centers in the brain, helping users reduce caloric intake

  • Delays gastric emptying, promoting longer feelings of fullness

• Potential Fitness Applications

  • May support body recomposition when combined with resistance training and proper nutrition by reducing fat mass without significant lean muscle loss

  • Could indirectly improve cardiovascular endurance through weight reduction and improved metabolic flexibility

• Liver & Cardiovascular Health (Emerging Areas)

  • Early indications of reduced liver fat content (beneficial for NAFLD)

  • Favorable trends in blood pressure, lipid profiles, and inflammatory markers